Disposition kinetics and optimal dosage of ciprofloxacin in healthy domestic ruminant species
2009
Javed, I.,University of Agriculture, Faisalabad (Pakistan). Dept. of Physiology and Pharmacology | Iqbal, Z.,University of Agriculture, Faisalabad (Pakistan). Dept. of Physiology and Pharmacology | Zia-ur-Rahman,University of Agriculture, Faisalabad (Pakistan). Dept. of Physiology and Pharmacology | Zargham Khan, M.,University of Agriculture, Faisalabad (Pakistan). Dept. of Pathology | Muhammad, F.,University of Agriculture, Faisalabad (Pakistan). Dept. of Physiology and Pharmacology | Aslam, B.,University of Agriculture, Faisalabad (Pakistan). Dept. of Physiology and Pharmacology | Sandhu, M.A.,University of Arid Agriculture, Rawalpindi (Pakistan). Dept. of Physiology | Sultan, J.I.,University of Agriculture, Faisalabad (Pakistan). Inst. of Animal Nutrition and Feed Technology
The purpose of this experimental study was to determine the disposition kinetics and optimal dosages of ciprofloxacin in healthy domestic ruminant species including adult female buffalo, cow, sheep and goat. The drug was given as a single intramuscular dose of 5 mg/kg. The plasma concentrations of the drug were determined with HPLC. The biological half-life was longer in cows (3.25+/-0.46 h) than in buffaloes (3.05+/-0.20 h), sheep (2.93+/-0.45 h) and goats (2.62+/-0.39 h). The volume of distribution in buffaloes was 1.09+/-0.06 L/kg, cows 1.24+/-0.16 L/kg, sheep 2.89+/-0.30 L/kg and goats 3.76+/-0.92 L/kg. Total body clearance expressed in L/h/kg was 0.25+/-0.02 in buffaloes, 0.31+/-0.02 in cows, 0.75+/-0.04 in sheep and 1.09+/-0.11 in goats. An optimal dosage regimen for 12-h interval consisted of 5.17, 5.62, 6.54 and 6.10 mg/kg body weight as priming and 4.84, 5.37, 6.26 and 5.91 mg/kg body weight as maintenance intramuscular dose in buffalo, cow, sheep and goat, respectively. The manufacturers of ciprofloxacin have claimed 5 mg/kg dose to be repeated after 24 h. However, the investigated dosage regimen may be repeated after 12 h to maintain MIC at the end of the dosage interval. Therefore, the optimal dosage regimen should be based on the disposition kinetics data determined for the species and environment in which a drug is to be employed clinically.
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