Cytokine response and clinicopathological findings in Brucella infected camels (Camelus dromedarius)
2009
El-Boshy, M.,Mansoura Univ. (Egypt). Faculty of Veterinary Medicine | Abbas, H.,Animal Health Research Inst., Cairo (Egypt) | El-Khodery, S.,Mansoura Univ. (Egypt). Faculty of Veterinary Medicine | Osman, S.,Kafrelsheikh Univ. (Egypt). Faculty of Veterinary Medicine
The aim of this study was to assess the cytokine response and selected clinicopathological findings associated with brucellosis in Camelus dromedarius. In total, 340 camels were examined for brucellosis using agglutination and Complement Fixation tests (CFT). Twenty-five camels (7.35%) were positive by both tests: 14 (4.12%) for B. abortus and 11 (3.23%) for B. melitensis. IL-1beta and IL-10 interleukin levels in both B. abortus and B. melitensis infected camels showed significant elevations compared with controls. Moreover, there was a significantly larger increase in IL-1beta interleukins in camels infected with B. abortus compared with B. melitensis. TNF-alpha, IFN-alpha and IL-1alpha levels showed significant decreases in Brucella infected camels compared with non-infected ones; however, there were non-significant changes in IL-6 levels in Brucella infected camels compared with controls. Lymphopenia was recorded in infected camels but not in controls. However, normocytic normochromic anemia, hypoproteinemia, hypoalbuminemia and hypoglycemia were recorded in the B. abortus group only. Sorbitol dehydrogenase (SD), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) showed significant increases in infected camels compared with controls, and in B. abortus infected camels compared with B. melitensis infected animals.
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