Effects of repeated overdoses of Kothala-himbutu [Salacia reticulata] extract in drinks
2008
Ozaki, S.(Fuji Sangyo Co. Ltd., Marugame, Kagawa (Japan)) | Tamura, H. | Kataoka, K.
To evaluate the safety of drinks containing the aqueous extract Kothala-himbutu (Salacia reticulata WIGHT), we conducted a double-blind study on the overdose of Kothala-himbutu over a 4-week period. A total of 54 subjects either healthy (n=27) or with borderline blood glucose levels and mild type 2 diabetes (n=27) were randomly assigned to untreated (placebo) or treated groups. Subjects consumed a drink containing the placebo or Kothala-himbutu extract powder (450 mg, 3 times the recommended amount) at breakfast and dinner every day. Continuous over doses of the drink containing Kothala-himbutu extract led to no significant clinical changes or adverse effects, such as hypoglycemia and gastrointestinal symptoms during the entire study period. However, the subjects with borderline blood glucose levels and mild type 2 diabetes in the treated group showed significant changes in the amount of HbAsub(1c) and glycoalbumin during the 4-week period compared to those of the placebo group (p0.05). In conclusion, this study suggests that continuous consumption of Kothala-himbutu extract is safe in healthy adults as well as those with borderline blood glucose levels and mild type 2 diabetes.
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