The Estrogenic Effects of Phthalates (DEHP, DBP) in MCF-7 Cell
2007
Lee, S.Y. (Kongju National University, Yeasan, Republic of Korea) | Kim, S.J. (Kongju National University, Yeasan, Republic of Korea) | Lee, S.H. (Kongju National University, Yeasan, Republic of Korea) | Park, Y.S. (Kongju National University, Yeasan, Republic of Korea) | Park, B.K. (Kongju National University, Yeasan, Republic of Korea) | Kim, B.S. (Kongju National University, Yeasan, Republic of Korea) | Kim, S.K. (Kongju National University, Yeasan, Republic of Korea) | Choi, C.S. (Chung-Ang University, Ansung, Republic of Korea) | Yoon, S.I. (Hanyang University, Seoul, Republic of Korea) | Kim, J.S. (Chonbuk National University, Jeonju, Republic of Korea) | Jung, J.W. (Seoul National University, Seoul, Republic of Korea) | Jung, J.Y. (Kongju National University, Yeasan, Republic of Korea), E-mail: [email protected]
To evaluate the estrogenic activities of di-ethyl hexyl phthalate (DEHP) and di-butyl phthalate (DBP), two phthalates known as endocrine disrupters, we used MCF-7 human breast cancer cell line. As results, DBP and DEHP had estrogenic effects. In brief, the concentration of maximal MCF-7 cell proliferation was 10∨-7M and 10∨-8M for DEHP and DBP, respectively. The ratio of maximal cell yield of the test compounds to that of 17β-estradiol was 87.5% for DEHP and 73.4% for DBP. In summary, both DEHP and DBP had cell proliferation potencies in the MCF-7 cell.
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