Evaluation of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations in dogs with mitral valve insufficiency
2009
Takemura, N.(Nippon Veterinary and Life Science Univ., Musashino, Tokyo (Japan). Faculty of Veterinary Medicine) | Toda, N. | Miyagawa, Y. | Asano, K. | Tejima, K. | Kanno, N. | Arisawa, K. | Kurita, T. | Nunokawa, K. | Hirakawa, A. | Tanaka, S. | Hirose, H.
The diagnostic significance of the plasma concentration of N-terminal pro-brain natriuretic peptide (NT-proBNP) was evaluated in 72 dogs with mitral valve insufficiency and 36 control dogs. In the controls, the plasma NT-proBNP concentration was 163.9 +- 114.7 (SD) pmol/l. The values in those with International Small Animal Cardiac Health Council (ISACHC) functional classification of heart failure class Ia, Ib, II and IIIa mitral valve insufficiency were 302.8 +- 257.1 (n = 21), 634.2 +- 642.5 (n = 23), 1,277.9 +- 756.2 (n = 18) and 1,908.9 +- 538.8 (n = 10) pmol/l, respectively; those in the class Ib or severer groups were significantly higher than that in the controls. In dogs in which the intensity of cardiac murmurs was Levine 3, 4, 5 and 6, plasma NT-proBNP concentrations were 647.6 +- 577.3 (n = 27), 1,184.7 +- 841.0 (n = 18), 1,532.4 +- 784.2 (n = 10) and 1,461.8 +- 932.2 (n = 4) pmol/l, respectively, and were significantly higher than that in the controls. The plasma NT-proBNP concentration was significantly correlated with the cardiac size (VHS) and LA/Ao (r = 0.611, n = 89, p 0.01; and r
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