Production of aflatoxins from Aspergillus flavus and acute aflatoxicosis in young broiler chicks
2008
Hussain, Z. (Livestock and Dairy Development, Toba Tek Singh (Pakistan)) | Khan, M.Z. (University of Agriculture, Faisalabad (Pakistan). Dept. of Pathology) | Zahoor-ul-Hassan (University of Agriculture, Faisalabad (Pakistan). Dept. of Pathology)
In the present study aflatoxins were produced by fermentation of rice. The highest average concentration of aflatoxins 131 was 763.157 mug/ g of rice in those flasks having addition of trace metals. Broiler chicks of 7 days of age were offered feed containing 0, 1600, 3200 and 6400 mug/ kg aflatoxin B1 for 7 days. Clinical signs in intoxicated birds included depression, ruffled feathers, decreased interest in feed, increased water intake and soft to watery feces. A significant decrease in body weight was observed in all groups which were in a dose related manner and it was more severe in group fed 6400 mug/ kg aflatoxins B1 in feed. Pathological lesions in birds of treatment groups included pallor discoloration of liver and enlargement of liver and kidneys. Hemorrhages were present on different organs of the body. Microscopically congestion of liver parenchyma, cytoplasmic vaculation/fatty change of hepatocytes, necrosis of hepatocytes, newly formed bile ducts, mononuclear and hetrophilic cell infiltration were observed in aflatoxin fed broiler chicks. Kidneys of aflatoxins B1 intoxicated birds were enlarged and microscopically revealed degeneration and necrosis of tubular epithelial cells, congestion and hemorrhages of the parenchyma. Present study revealed that all the clinical, gross and histopathological lesions were dose related.
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