Morphological findings in the cranial mesenteric artery of horses with verminous arteritis
2009
Marinkovic, D. | Aleksic-Kovacevic, S. | Krstic, V. | Knezevic, M., University of Belgrade, Belgrade (Serbia). Faculty of Veterinary Medicine
Cranial mesenteric arteries of 18 sacrificed necropsied horses of both sexes and different age groups were described in this ppaer. Enlarged, thickened cranial mesenteric arteries with a hard-elastic consistency and narrowed lumen, were macroscopically evident in all examined sick horses. Live larvae of Strongylus vulgaris, situated free in the lumen, or attached to the intima of the blood vessel or incroporated in the thrombus were noted macroscopically in 37.5% examined sick horses. Inflammatory and fibrous changes were noticed and were present in the intima, media and adventitia of the blood vessel. The inflammatory infiltrate in the intima of the cranial mesenteric artery consisted of eosinophils, macrophages, plasma cells, lymphocytes and rare multinucleated giant cells and was situated mostly close to the Strongylus vulgaris larvae. Beside inflammatory changes, intimal fibrosis and extension, characterized by increased proliferation of alfa-SMA positive cells, was notable. Lesions of the internal elastic lamina consequently led to an inflammatory and fibrotic reaction in the tunica media. Fibrosis of the media characterized by the presence of connective tissue cells and fibers, as well as smooth-muscle cells, was present in 93.75% examined sick horses. Inflammation and fibrosis were mildest in the adventitia. Lesions of vasa vasorum were present in 81.25% examined sick animals were characterized by fibrosis, obliteration, perivascular cellular infiltration, mostly with eosinophils and findings of intimal bodies. All described changes are characteristic for cranial mesenteric artery verminous arteritis.
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