Effect of protamine sulphate on the isolated mesenteric arteries of normotensive and spontaneously hypertensive rats
2008
Orescanin-Dusic, Z., Institute for Biological Research Sinisa Stankovic, Belgrade (Serbia). Department of Physiology | Milovanovic, S., University of Eastern Sarajevo, Foca (Bosnia and Herzegovina). Faculty of Medicine | Spasic, M., University of Belgrade, Belgrade (Serbia). Faculty of Chemistry | Radojicic, R., University of Belgrade, Belgrade (Serbia). Faculty of Biology | Blagojevic, D., Institute for Biological Research Sinisa Stankovic, Belgrade (Serbia). Department of Physiology
We tested relaxant effect of increased protamine sulphate (PS) amounts (10, 20, 50, 100 and 150 microgram/ml) on the isolated mesenteric arteries of normotensitive and spontaneously hypertensive (SH) rats, with or without endothelium. PS caused concentration-dependent relaxation of isolated mesenteric arteries in both types of rats. The relaxation effect of PS was lower in SH rats than in normotensive ones. Our results indicate that the vascular smooth muscles play a significant role in PS-mediated relaxation.
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