USE OF MYCOBACTERIUM VACCAE (SRL172) AS AN IMMUNOMODULATING AGENT IN ASSOCIATION WITH MURINE MELANOMA MODEL B16-F10
2000
BABAN, B., Tehran University of Medical Sciences. Tehran. Iran. | SOUBERBIELLE, B., Tehran University of Medical Sciences. Tehran. Iran. | SHARAFI, J., Tehran University of Medical Sciences. Tehran. Iran. | MOHAGHEGH HAZRATI, S., Tehran University of Medical Sciences. Tehran. Iran. | SAFARAN, M., Tehran University of Medical Sciences. Tehran. Iran.
Because of immunotherapeutic effects of Mycobacterium vaccae (M. vaccae) by inducing Th1 responses, we tried a heat-killed suspension of M. vaccae in mice models (C57BL/6J), which had already been challenged by tumor cell lines B16-F10. The Immunization consisted of subcutaneous injection of irradiated B16-F10 cells, as an antigen, plus M. vaccae into the tail base at two inguinal sites of mice, which were injected by live wild type B16-F10 cells. Survival and tumor growth was recorded every three days for a period of three months. Increase in survival was observed whilst decrease in tumor growth was recorded. The result indicates that the heat-killed suspension of the bacterium is a powerful immunological adjuvant.
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