Sdudy on efficacy of theilerin in delayed hypersensitivity of bovine theileriosies
1999
Hashemi Fesharaki, Reza, Razi Vaccine and Serum Reseach Institute - RVSRI | Habibi, GH.R., Razi Vaccine and Serum Reseach Institute - RVSRI | Barmalaie, Razi Vaccine and Serum Reseach Institute - RVSRI | Rezaie, Razi Vaccine and Serum Reseach Institute - RVSRI | Kamali, M.R., Razi Vaccine and Serum Reseach Institute - RVSRI
Freeze- dired schizont tissue culture antigen of T.annulate (theilerin) was prepared and its total nitrogen was deretmined at a level of mg/ml.292 calves, heifers, milking cows aleardy vaccinated against theileriosis or recoveredfrom acute theileriosis were chosen. they were divied into three groups which respectively received 0.1 ml of theilerin intradermally at normal concentration total nitrogen and also two other dilutions (1.10 and 1.100). pathological changes such as thickness, erythema, cells infiltration and lymphadenopathy on the inoculation site and also general condition of the animals were checked 48 and 72 hours post inoculation. 62.5% of cattle receiving theilerin at a levelof normal concentration shwed more then one mm increase in skin thickness at the site of inoculation, the mean value of which com to 3.48 mm. the rest of the animals showed askin thickness increase of 1mm which can be concidered negligible. the pathological examination of the inoculation site skin showed in filtration of lymphocytes. the results indicated that the test in positive and could be used as on accuracy test for checking the immunity in vaccinated animals provided that the cell-mediated immunity theileria annulata is defenitly protective.
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