Experimental Study On Preparing Oral Vaccines Of Diphtheria And Tetanus Instead Of Injecting Vaccines In Animals
2000
Mirshamsy , Hossein
Purified diphtheria toxoid incorporated in egg yolk and mixed with medical plamt seed (London rocket seed LRS) was used to orally immunized rabbits against diphtheria infection. Animal were partially immunized against a Lethal diphtheria toxin challenge. The immunity was complete when gastric enzymes juices were inhibited before oral vaccination by aprotinin a natural protease inhibitor. Rabbits and monkeys were orally immunized against both diphtheria and tetanus in the same way by pretreatment with aprotinin. Adult volunteers receiving protease inhibitor. before administration of aral toxoids have shown a Significant rise in specific circulating antitoxins.2) In a prelininary study, Adjuvnat effects of liposomes on the systemic and mucosal inmune response have been studid when a mixture of diphtheria toxoid (DT) and tetanus toxoid (IT) entrapped in Liposomse were administered parenterally or orally in rabbit a significant Rise of specific antibodies against both toxoids was noticed. In monkeys naceiving a mixture of DT and IT entrapped in Liposomes orally the antibody response after 2 and 3 ingestions of this product was mild but when Liposomes containing toxoids were adsorbed with aluminium hydroxide in a similar experiment, a Significant rise in the specific antibody response in monkey against both toxoids was recorded. Adult volunteers Similarly Receiving a mixture of DT and IT entrapped in Liposomes, and adsorbed with aluminium hydroxide have shown a significant rise in specific Circvlatiny antitoxins... 3) In a comparative study of 2 adjuvants : LRS and PGPI-MC, the antibody response of monkeys receiving Dt and IT combined were investigated the an.ti-diphtheria antitoxin responses of monkeys receving DT and IT combined with 50 mg/kg of PGPL-MC or 50 mg/kg of LRS were significantly increased...
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