Protective effect of selenium on antioxidant defense system in the blood of rats treated with cadmium
2006
Ognjanovic, B.I. | Markovic, S.D., University of Kragujevac, Kragujevac (Serbia). Faculty of Sciences, Institute of Biology and Ecology | Pavlovic, S.Z., Institute for Biological Research Sinisa Stankovic, Belgrade (Serbia). Department of Physiology | Zikic, R.V. | Stajn, A.S., University of Kragujevac, Kragujevac (Serbia). Faculty of Sciences, Institute of Biology and Ecology | Ziemnicki, K., University of Poznan (Poland). Faculty of Biology, Institute of Experimental Biology | Petrovic, V.M. | Saicic, Z.S., Institute for Biological Research Sinisa Stankovic, Belgrade (Serbia). Department of Physiology
The effect of cadmium (Cd, 15 mg/kg/day) on the blood antioxidant defense system and possible protective effects of selenium (Se, 7 microg/kg/day) were studied. Chronic Cd administration resulted in increased activities of copper, zinc superoxide dismutase (CuZn SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in red blood cells (RBC), as well as glutathione S-transferase (GST) activity and vitamin E (Vit E) concentration in the plasma. Se induced a significant increase in GSH-Px and GST activities, as well as concentrations of vitamin C and E. Thus, the mechanism by which Se decreases Cd toxicity in rats, seems to rely on the protection of the antioxidant defense system in blood, possibly by forming non-toxic cadmium selenide. The accumulation of Cd in RBC also decreased significantly upon co-exposure to Se. The obtained results show, that Cd exhibit toxic effects on the antioxidant defense system in the blood of rats and that Se demonstrates the protective effect against toxicity.
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