Examination of genotoxic effects of fumagillin in vivo
2009
Kulic, M., University of Sarajevo, East Sarajevo (Bosnia and Herzegovina). Faculty of Medicine | Aleksic, N., University of Belgrade, Belgrade (Serbia). Faculty of Veterinary Medicine | Stanimirovic, Z., University of Belgrade, Belgrade (Serbia). Faculty of Veterinary Medicine | Ristic, S., University of Sarajevo, East Sarajevo (Bosnia and Herzegovina). Faculty of Medicine | Medenica, S., University of Sarajevo, East Sarajevo (Bosnia and Herzegovina). Faculty of Medicine
Fumagillin is an antibiotic derived from the fungus Aspergillus fumigatus. In this research fumagillin was tested for the ability to provoke chromosomal aberrations in mouse bone marrow. BALB/c mice were administered fumagillin by gastric probe in doses of 5, 10 and 20 mg/kg b.w. Water-sugary syrup was the negative and cyclophosphamide (15 mg/kg b.w.) the positive control. Significantly increased frequencies of numerical chromosomal aberrations was observed in both in medium (10 mg/kg b.w.) and in the highest (20 mg/kg b.w.) dose of fumagillin. Structural chromosomal aberrations were noticeably more frequent in comparison to negative control only in the highest experimental dose of dicyclohexilamine. These results clearly showed that fumagillin in concentrations of 10 and 20 mg/kg b.w. had a genotoxic potential in vivo.
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