Evaluation of flunixin meglumine genotoxicity using in vitro and in vivo/in vitro micronucleus test
2009
Aydin, S.A., Istanbul University, Istanbul (Turkey). Faculty of Veterinary Medicine | Ustuner-Keles, O., Istanbul University, Istanbul (Turkey). Faculty of Veterinary Medicine
The aim of this study was to investigate the genotoxic effects of flunixin meglumine on mice peripheral lymphocytes by in vitro and in vivo/in vitro cytokinesis block micronucleus tests (CBMN). Flunixin meglumine was used at concentrations of 25, 50 and 100 microgram/mL for the in vitro assay and 50, 75 and 100 mg/kg for the in vivo/in vitro assay. According to the results, flunixin meglumine is genotoxic in mice lymphocytes treated in vitro, but has not mutagenic activity in vivo under micronucleus (MN) test conditions.
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