Determination of flumequine residues in broiler chickens with HPLC and screening method
2009
Petrovic, J., Scientific Veterinary Institute Novi Sad, Novi Sad (Serbia) | Baltic, M., University of Belgrade, Belgrade (Serbia). Faculty of Veterinary Medicine | Stefanovic, S., Institute of Meat Hygiene and Technology, Belgrade (Serbia) | Milanov, D., Scientific Veterinary Institute Novi Sad, Novi Sad (Serbia) | Ratajac, R., Scientific Veterinary Institute Novi Sad, Novi Sad (Serbia)
The aim of this study was to examine the target tissue residues of flumequine, according to MRL values, to eliminate health risk for the consumers. The presence of flumequine in breast muscle and liver was detected by microbiological inhibition assay and HPLC method. Chickens were used to examine tissue depletion of flumequine after multiple oral doses (12 mg/kg bw every 24 h for 5 days). After the end of oral administration, hepatic concentrations of flumequine (1760-90 ng/g) persisted for 3 days; at the time, flumequine residues were also detected in muscle tissue (980-40 ng/g). Flumequine concentrations in breast muscle and liver exceeded the MRL values only on the first day of the withdrawal period. Microbiological method - plate pH 8.0 with E. coli NCIMB 11595 revealed positive results in all samples with residue concentrations above MRL values. Two days of withdrawal period allowed time for the drug concentrations in meat and liver to decrease to an acceptable level prior to slaughter (below MRL).
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