In vitro incidence of chromosome aberrations in gamma-irradiated rabbit lymphocytes, treated with Haberlea rhodopensis extract and vitamin C
2010
Popov, B., Thracian University, Stara Zagora (Bulgaria) | Radev, R., Thracian University, Stara Zagora (Bulgaria) | Georgieva, S., Thracian University, Stara Zagora (Bulgaria)
Ionizing radiation produce deleterious effects in the living organisms and the rapid technological advancement has increased human exposure to ionizing radiation enormously. There is a need to protect humans against such effects of ionizing radiation. In this study, the effect of Haberlea rhodopensis and vitamin C on the frequency of chromosome aberrations in rabbits peripheral blood lymphocytes after in vitro gamma irradiation was compared. Results demonstrated that H. rhodopensis extract - at concentrations 1.0 μl/ml, 4.0 μL/mL and 8.0 μL/mL reduced the frequency of chromosome aberrations, especially double chromosome fragments and dicentrics, as well as aberrant cells. H. rhodopensis extract applied at 1.0, 4.0 and 8.0 μL/mL was found to be more effective in reducing aberrant cells than vitamin C - 1.0 μg/mL. The effect of H. rhodopensis and vitamin C on the frequency of dicentrics and double acentric fragments was similar. It can be concluded that the extract of H. rhodopensis at tested concentrations showed a radioprotective potential.
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