Protective effects of carnosine and homocarnosine on ferritin and hydrogen peroxide-mediated DNA damage
2010
Kang, J.H., Cheongju University, Cheongju, Republic of Korea
Previous studies have shown that one of the primary causes of increased iron content in the brain may be the release of excess iron from intracellular iron storage molecules such as ferritin. Free iron generates ROS that cause oxidative cell damage. Carnosine and related compounds such as endogenous histidine dipetides have antioxidant activities. We have investigated the protective effects of carnosine and homocarnosine against oxidative damage of DNA induced by reaction of ferritin with H₂O₂. The results show that carnosine and homocarnosine prevented ferritin/H₂O₂-mediated DNA strand breakage. These compounds effectively inhibited ferritin/H₂O₂-mediated hydroxyl radical generation and decreased the mutagenicity of DNA induced by the ferritin/H₂O₂ reaction. Our results suggest that carnosine and related compounds might have antioxidant effects on DNA under pathophysiological conditions leading to degenerative damage such as neurodegenerative disorders.
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