The effects of some premedication and general anaesthesia drugs on intraocular pressure and pupil diameter in dog's eyes | Acs iekšējā spiediena un acs zīlītes diametra izmaiņas suņiem dažu premedikācijas un vispārējās anestēzijas līdzekļu ietekmē
2011
Kovalcuka, L., Latvia Univ. of Agriculture, Jelgava (Latvia). Faculty of Veterinary Medicine. Preclinical Inst. | Birgele, E., Latvia Univ. of Agriculture, Jelgava (Latvia). Faculty of Veterinary Medicine. Preclinical Inst.
The objective of the study was to determine the effects of the premedication and general anaesthesia combination on intraocular pressure (IOP) and horizontal pupil diameter (HPD) in dog's eyes. Ten dogs of different age and sex were used, and all animals were approved for a planned surgery – castration or ovariohisteroectomy. For premedication, the combination of 0.1% atropine sulphate and 1% acepromazine maleate solution was used intramusculary, but for general anesthesia – 10% ketamine hydrochloride together with 0.5% diazepam solution was used intravenously. Ten clinically healthy dogs with a similar weight and age were used as a control. Instead of premedication and general anaesthesia, 0.9% NaCl solution was injected. It was established that the combination of atropine sulphate and acepromazine maleate causes irregular changes in the intraocular pressure. A significant and rapid IOP increase was obtained in both eyes immediately after intravenous injection of general anaesthesia – combination of ketamine hydrochloride and diazepam. Premedication induces small and fluctuating changes in the horizontal pupil diameter in both eyes, but ketamine hydrochloride together with diazepam significantly increased it. The premedication and general anaesthetic drugs cause a significant increase in the intraocular pressure, therefore their administration in dogs should be considered in various eye pathologies.
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