Evaluation of toxic effects of Trigonella foenum-graecum leaf aqueous extract on development of long bone tissue in rat fetus
2010
Mozaffari, Z. (Islamic Azad Univ., Hamedan (Iran). Dept. of Biology) | Azarnia, M. (Tarbiat Moallem Univ., Tehran (Iran). Dept. of Biology) | Angaji, S.A. (Tarbiat Moallem Univ., Tehran (Iran). Dept. of Biology)
In the present study, the adverse effects of Trigonella foenum-graecum leaves aqueous extract (TGLE) on the organogenesis stage of Sprague-Dawley rat fetus was investigated; particularly, the effect on fetal development of the hind limb long bone. TGLE was administered in pregnant rats by intra peritoneal (i.p.) injection at the dose levels of 0.8, 1.6 and 3.2 (g / kg / day) on the 10th day of gestation. Then all rats were sacrificed on the 20th day of gestation and fetuses were removed from their uterus. The fetuses were assayed for histopathological signs of long bone. The results indicated that the treatment with TGLE (3.2 g / kg / day) were significantly different in long bone structure and growth histology details disorder in comparison with the, control group (p less than 0.001). The treated group showed a correlation with the histopathological changes of long bone tissue in their fetuses.
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