Gastroprotective effects of novel antidotal combination in rats acutely poisoned by T-2 toxin
2010
Jaćević, V., Military Medical Academy, Belgrade (Serbia). National Poison Control Centre | Resanović, R., Faculty of Veterinary Medicine, Belgrade (Serbia) | Bočarov-Stančić, A., Bio-Ecological Center, Zrenjanin (Serbia) | Đorđević, S., Military Medical Academy, Belgrade (Serbia). National Poison Control Centre | Dragojević-Simić, V., Military Medical Academy, Belgrade (Serbia). Centre for Clinical Pharmacology | Vukajlović, A., Military Medical Academy, Belgrade (Serbia). National Poison Control Centre | Bokonjić, D., Military Medical Academy, Belgrade (Serbia). National Poison Control Centre
The purpose of this experiment was to evaluate the antidotal potencies of methylprednisolone (soluble form, Lemod-solu(R)), nimesulide, N-acetylcysteine (Fluimucil(R)) and their combinations in rats treated with 1.0 LD50 (0.23 mg/kg) of trichothecene mycotoxin, T-2 toxin. Their antidotal efficacy was investigated by monitoring their effects on general condition, 24-hour-survival, body weight gain, food and water consumption and pathohistological changes in the gut of Wistar rats acutely treated with a single injection of T-2 toxin during a 4-week period. The results clearly show that methylprednisolone, a well-known anti-inflammatory and immunosuppressive drug, exerts the best antidotal effect against T-2 toxin intoxication in rats.
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