The expression of muscle ankyrin repeat proteins in brown adipose tissue
2011
Rakićević, Lj., Institute of Molecular Genetics and Genetic Engineering, Belgrade (Serbia) | Petrović, N., Stockholm University, Stockholm (Sweden). Wenner–Gren Institute | Radojković, D., Institute of Molecular Genetics and Genetic Engineering, Belgrade (Serbia) | Kojić, S., Institute of Molecular Genetics and Genetic Engineering, Belgrade (Serbia)
MARP family members CARP, Ankrd2 and DARP are expressed in the striated muscle, while DARP protein is also detected in brown adipose tissue (BAT). Taking into account recent findings concerning the common origin of muscle and brown fat, expression of CARP and Ankrd2 in mouse BAT was investigated. We demonstrated Ankrd2 expression in both inactive and thermogenically active BAT, while CARP expression was not detected. Our findings suggest that the expression of Ankrd2 in BAT could be a part of the myogenic transcriptional signature, further supporting the evidence that muscle and brown adipose cells arise from the same myoblastic precursor.
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