Time- and dose-dependent toxicity of sulfonamide - characteristic of metabolic profile in Wistar rats
2010
Stojanović, D., Faculty of Agriculture, Novi Sad (Serbia) | Kovačević, Z. | Cincović, M.R., Faculty of Agriculture, Novi Sad (Serbia) | Belić, J. | Vidović, V.
The experiment has entered 96 rats Wistar strain. Formed four groups one control (C) and three experimental which was received 0.066% (O1), 0.2% (O2) and 0.6% (O3) sulfadiminid-sodium in drinking water for 8 weeks. The blood was sampled in which were determined by the following parameters: iron, triglycerides, cholesterol, urea, uric acid, creatine and alkaline phosphatase. It was done measuring the body mass of rats. Also, it was measured absolute mass of liver, kidney, spleen, heart and tymus. Toxic effects of sulfonamides were seen in nephrotoxicity and probably hepatotoxicity, taking into account the mass of organs and characteristics of the metabolic profile. Toxicity is expressed depending on the dose. Exposure time was not significant in animals that received the optimal dose or less.
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