The effect of aminoguanidine, an inducible nitric oxide synthase inhibitor, on AlCl3 toxicity in the rat hippocampus
2010
Stevanović, I.D., Military Medical Academy, Belgrade (Serbia). Institute for Medical Research | Jovanović, M.D., Military Medical Academy, Belgrade (Serbia). Institute for Medical Research | Čolić, M., Military Medical Academy, Belgrade (Serbia). Institute for Medical Research | Jelenković, A., Institute for Biological Research, Belgrade (Serbia) | Mihajlović, R., Institute for Rehabilitation, Belgrade (Serbia) | Stojanović, I., Faculty of Medicine, Niš (Serbia) | Ninković, M., Military Medical Academy, Belgrade (Serbia). Institute for Medical Research
The presented experiment was carried out to determine the effectiveness of the inducible nitric oxide synthase inhibitor - aminoguanidine in modulating the toxicity of aluminium chloride on the nitrite levels, malondialdehyde concentration, reduced gluthatione content, as well as cytochrome c oxidase (COX) activity of Wistar rats. The animals were killed 3 h and 30 days after treatment and the hippocampus was removed. The biochemical results show that aluminium acts as a pro-oxidant, while aminoguanidine exerts an antioxidant action in aluminium chloride-treated animals. We have also applied immunohistochemical techniques to identify iNOS expression after the treatment. Our data suggest that aminoguanidine can be effective in the protection of toxicity induced by aluminium chloride.
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