Immunohistochemical profile of multicentric cutaneous epitheliotropic T-cell lymphoma with generalised lymphadenopathy in a Holstein-Friesian cow: a case report
2012
Otrocka-Domagala, I., University of Warmia and Mazury, Olsztyn (Poland). Faculty of Veterinary Medicine | Procajlo, Z., University of Warmia and Mazury, Olsztyn (Poland). Faculty of Veterinary Medicine | Pazdzior, K., University of Warmia and Mazury, Olsztyn (Poland). Faculty of Veterinary Medicine | Gesek, M., University of Warmia and Mazury, Olsztyn (Poland). Faculty of Veterinary Medicine | Rotkiewicz, T., University of Warmia and Mazury, Olsztyn (Poland). Faculty of Veterinary Medicine | Szweda, W., University of Warmia and Mazury, Olsztyn (Poland). Faculty of Veterinary Medicine
Cutaneous epitheliotropic T-cell lymphoma with progression to superficial and internal lymph nodes and the spleen was diagnosed in a two-year-old Holstein-Friesian cow. The skin lesions included multiple hypotrichous to alopecic nodules, often with ulceration, which first appeared three months after calving and progressed quickly to cover the entire body. The cow was euthanized one month later. The ELISA test excluded bovine leukaemia virus infection. Histologically, the formation of Pautrier's microabscesses was observed in the epidermis and dense neoplastic infiltration with mild folliculotropism was observed in the dermis. Similar neoplastic cells were present in the histological sections of lymph nodes and spleen. Immunohistochemical analysis was performed using CD3, CD79alphacy, HLA-DR, WC1-N3 and Ki67 antibodies. Immunophenotyping results (CD79alphacy-, CD3+, WC1-N3-) confirmed the alphabeta T-cell origin of neoplastic cells. The mean Ki67 index among neoplastic cells was 15.3%. On the basis of the immunohistochemical and histopathological results, the first case in Poland of cutaneous epitheliotropic T-cell lymphoma in a cow was confirmed. Additionally, MHC class II expression on approximately 10.4% of lymphoma cells was associated with a poor clinical prognosis. However, the up-regulation of MHC class II expression on accompanying cells suggested tumour immune surveillance, an antigen-specific immune response or immunosuppression.
Mostrar más [+] Menos [-]Palabras clave de AGROVOC
Información bibliográfica
Este registro bibliográfico ha sido proporcionado por Library of Antonin Svehla