Development and pilot production of live infectious bursal disease (Gumboro) vaccine.
2009
Ebrahimi, Mohammad Majid | Moqaddam Pur, Mas`ud | Ebrahimi, Reza | Mas`udi, Shahin | Shah Savandi, Shahla | Pishraft Sabet, Leyla | Afkhami, Mohammad A`li
Infectious bursal disease (IBD) is an acute contagious viral disease of birds. Vaccination is the main strategy for prevention of the disease. Because all of two milliard doses of IBD vaccine are imported, it is decided to produe it in Iran. In this regard, the virus seed was propagated in SPF egg. Diagnostic serological tests (VN and AGID), electron microscopy and molecular examinations were done. Then, the bacteriology, purity, titration, reversion to virulence, bursa-body index, immunosupression and efficacy tests were performed on this sample. The results indicated that the vaccine virus is an intermediate strain. Dose of the IBD vaccine was set up on SPF chickens. The laboratory trial was scaled and the clinical trial was done three times with different ways. These results were compared with an imported intermediate IBD vaccine. According to serological assays and challenge, the developed IBD vaccine induces an adequate immunity in both SPF and commercial chickens and had no adverse effects. Also, it is found there is no significant difference between the developed IBD vaccine and an imported one.
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