Protective effect of the methanol extract of Polyopes lancifolia (Harvey) kawaguchi et wang against ionizing radiation-induced mouse gastrointestinal injury
2011
Jeong, J.W., Jeju National University, Jeju, Republic of Korea | Yang, W.J., Jeju National University, Jeju, Republic of Korea | Ahn, M.J., Jeju National University, Jeju, Republic of Korea | Kim, K.C., Jeju National University, Jeju, Republic of Korea | Hyun, J.W., Jeju National University, Jeju, Republic of Korea | Kim, S.H., Chonnam National University, Gwangju, Republic of Korea | Moon, C.J., Chonnam National University, Gwangju, Republic of Korea | Shin, T.K., Jeju National University, Jeju, Republic of Korea
The radioprotective efficacy of a methanol extract of the red algae Polyopes lancifolia (Harvey) kawaguchi et wang (mPL) was evaluated in mice subjected to total-body gamma irradiation. mPL protection against radiation-induced oxidative stress was examined by histological evaluation of intestinal crypt-cell survival and liver activities of the antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT). mPL (100 mg/kg body weight) administered intraperitoneally at 24 h and 1 h prior to irradiation protected jejunal crypt cells from radiation-induced apoptosis (p less than 0.01). The pretreatment of mPL attenuated a radiation-induced decrease in villous height (p less than 0.05), and improved jejunal crypt survival (p less than 0.05). The dose reduction factor was 1.14 at 3.5 days after irradiation. Treatment with mPL prior to irradiation resulted in significantly higher (p less than 0.01) levels of SOD and CAT activities, compared to those levels of irradiated control mice with vehicle treatment. These results suggest that mPL is a useful radioprotective agent capable of defending intestinal progenitor cells against total-body irradiation, at least in part through mPL antioxidative activity.
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