Fallvorstellung: Bovine Leukozyten-Adhaesions-Defizienz (BLAD) in der Schweiz.
1997
Meylan M. | Abegg R. | Sager H. | Jungi T.W. | Martig J.
Bovine Leukocyte Adhesion Deficiency (BLAD) Syndrome is a lethal congenital immunodeficiency caused by the strong reduction in the expression of leukocyte integrins (beta 2 integrins) on the surface of leukocytes. Therefore, neutrophils from BLAD animals lack the capacity to adhere to the endothelium, a necessary step in their emigration into foci of infection. Due to the virtual absence of neutrophil-mediated host defense, animals suffer from recurrent infection of the respiratory and gastrointestinal tracts and finally succumb to infections. A 14-day-old Holstein-Friesian calf showing omphalophlebitis and leukocytosis was referred to our clinic. It was found to suffer from several febrile episodes of infection. The tentative diagnosis BLAD could be confirmed for the first time in Switzerland by flow cytometry, pedigree analysis, and by restriction fragment length polymorphism.
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