Labaratory [i.e. Laboratory] diagnostics of inflammation | Laboratorijska dijagnostika inflamacije
2011
Kovačević-Filipović, M., Fakultet veterinarske medicine, Beograd (Serbia) | Francuski, J., Fakultet veterinarske medicine, Beograd (Serbia)
Local and systemic inflammatory response is non-specific response of living tissue to endogenous and exogenous damaging factors. Inflammatory response could be manifested with a number of clinical signs and hematological and biochemical changes in plasma (serum) that can be diagnosed in routine clinical and in experimental laboratories. This paper aims to describe the classical hematological and biochemical changes that occur in dogs and cats during the acute and chronic inflammation and to underline main changes that could be used to estimate the intensity of inflammation and/or to identify subclinical inflammation process. Basic laboratory parameters that can be used to diagnose the presence and severity of inflammation are: total number of leukocytes, differential leukocyte counts, morphology of leukocytes in blood smear, platelet number, fibrinogen concentration, erythrocyte sedimentation rate. Less commonly used parameters are: CRP concentration (in dogs), acid glycoprotein concentration (in cats), albumin/globulin ratio and changes in red blood cells. Assessment of severity of inflammation and diagnosis of subclinical inflammation can be done only by applying a combination of all stated parameters.
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