Novel anticancer compounds from marine actinomycetes : A Review
2011
Jemimah Naine.S, V. Mohana Srinivasan | C. Subathra Devi *.
It is increasingly evident that the true biological origin of many metabolites isolated from certain marine microorganisms. The prokaryotic marine actinomycetes continue to be an important source of bioactive secondary metabolites and potent cytotoxic compounds. These antitumor compounds belong to several structural classes such as polyketides, non-ribosomal peptides, indolocarbazoles, isoprenoides, and others. The medical and pharmaceutical application of these compounds were investigated for a few decades, This review presents a total of 35 anticancer metabolites, belonging mainly to the structural class, which mainly emphasis on their biological activities of the anticancer metabolites against cytotoxic cells isolated from marine actinomycetes from different places between January 2005 and December 2009. This new innovations in the research field will provide valuable and novel insight into the marineactinomycetes dynamics as well as a new approach to comprehending biodiversity which reveals the presents trends on the role of anticancer compounds for the potential lead.
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