The effect of acute exposure to herbicide Gardoprim Plus Gold 500 SC on haematological and biochemical indicators and histopathological changes in common carp (Cyprinus carpio L.)
2011
Dobsikova, R., Veterinarni a Farmaceuticka Univ., Brno (Czech Republic). Ustav Verejneho Veterinarniho Lekarstvi a Toxikologie | Blahova, J., Veterinarni a Farmaceuticka Univ., Brno (Czech Republic). Ustav Verejneho Veterinarniho Lekarstvi a Toxikologie | Modra, H., Veterinarni a Farmaceuticka Univ., Brno (Czech Republic). Ustav Verejneho Veterinarniho Lekarstvi a Toxikologie | Skoric, M., Veterinarni a Farmaceuticka Univ., Brno (Czech Republic). Ustav Patologicke Morfologie a Parazitologie | Svobodova, Z., Veterinarni a Farmaceuticka Univ., Brno (Czech Republic). Ustav Verejneho Veterinarniho Lekarstvi a Toxikologie
The study was focused on the assessment of effects of herbicide preparation Gardoprim Plus Gold 500 SC (terbuthylazine and S-metolachlor as active substances) on haematological and biochemical indices as well as tissue histopathological changes in Cyprinus carpio. Forty eight one- to two-year-old fish were divided into two groups, i.e. 24 fish were treated with 13.0 mg/L of Gardoprim Plus Gold 500 SC and 24 fish were used in control. The experiment was conducted according to OECD method No. 203 Fish, Acute Toxicity Test. Experimental carp showed a significant decrease in leukocyte and lymphocyte counts and haematocrit value in haematological profile. In biochemical indices, a significant increase in glucose, aspartate aminotransferase, ammonia and lactate dehydrogenase, and a significant decrease in inorganic phosphorus, triglycerides, and chlorides were found in exposed carp compared to control. Histopathological examination revealed lesions in gills and liver. The decline in both leukocyte and lymphocyte counts indicates decreased nonspecific immunity of treated common carp. Increase in ammonia and glucose concentrations, and in catalytic activities of lactate dehydrogenase and aspartate aminotransferase can be related to stress burden, and alteration of liver cell function.
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