Hepatoprotective role of milk thistle (Silybum marianum) in meat type chicken fed aflatoxin B1 contaminated feed
2012
Muhammad, D. (KPK Agricultural Univ., Peshawar (Pakistan). Dept. of Poultry Science) | Chand, N. (KPK Agricultural Univ., Peshawar (Pakistan). Faculty | Khan, S. (KPK Agricultural Univ., Peshawar (Pakistan). Dept. of Poultry Science) | Sultan, A. | Mushtaq, M. | Rafiullah
Milk thistle was added in aflatoxin B1 contaminated poultry feed to investigate and compare its hepatoprotective effects with a commercial toxin binder. Two hundred and forty, day-old broilers were randomly allocated into four major groups A, B, C and D. Group A was kept as control, having aflatoxin free feed, while group B was fed aflatoxin contaminated feed, group C was raised on aflatoxin contaminated feed with toxin binder "Mycoad" @ 3g/kg of feed, while group D was provided aflatoxin contaminated feed along with milk thistle @ 10g/kg of feed. Aflatoxin B1 was present at the level of 80 mug/kg feed during the first week and 520 mug/kg feed in the remaining experimental period. Serum total protein was significantly (P less than 0.05) higher in group D, followed by group A, C and B. Serum enzymes including, alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) values were significantly (P less than 0.05) lower in group D, followed by C, A and B, which are indicative of hepatoprotective role of milk thistle. Body weight gain and feed intake was decreased by aflatoxin contaminated feed (group B) in comparison with group A and group D. Milk thistle supplementation improved body weight gain and feed intake and was similar to toxin binder treated birds. Average feed conversion ratio (FCR) was significantly (P less than 0.05) higher (poor) in group B and were the same in all other groups. Present study demonstrated that milk thistle can potentially be used as mycotoxin binder and to minimize the adverse effects of toxin contaminated feed in broilers production.
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