Effect of Dongchunghacho (Cordyceps militaris) on hyperglycemia and dyslipidemia in type 2 diabetic db/db mice
2012
Choi, H.N., Inje University, Gimhae, Republic of Korea | Kang, M.J., Changwon National University, Changwon, Republic of Korea | Jeong, S.M., Inje University, Gimhae, Republic of Korea | Seo, M.J., Dong-A University, Busan, Republic of Korea | Kang, B.W., Dong-A University, Busan, Republic of Korea | Jeong, Y.K., Dong-A University, Busan, Republic of Korea | Kim, J.I., Inje University, Gimhae, Republic of Korea
Controlling hyperglycemia and dyslipidemia is associated with reduced risks for diabetic complications. The present study examined the effect of dongchunghacho (Cordyceps militaris; CM) on hyperglycemia and dyslipidemia in an animal model of type 2 diabetes. Fiveweek-old db/db mice were fed an AIN-93G diet or a diet containing 1% CM water extract, whereas db/+ mice were offered the AIN-93G diet for 6 weeks. Consumption of CM significantly decreased blood glycated hemoglobin and serum glucose levels, as well as homeostasis model assessment for insulin resistance (HOMA-IR), in db/db mice. CM significantly lowered serum triglyceride and total cholesterol levels, and increased HDL-cholesterol level. CM water extract inhibited rat intestinal α-glucosidase, with an IC∧50 of 182 ㎍/mL in vitro. These results indicate that CM exerted hypoglycemic and hypolipidemic effects in db/db mice.
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