Development of probiotic microcapsules with calcium alginate and prebiotics using modern optimization techniques.
2004
Chiou, H. Y. | Chen, M. J. | Lin, C. W. | Chen, K. N.
The prebiotics (peptides, fructooligosaccharides, isomaltooligosaccharides) were incorporated with calcium alginate as wallmaterials to microencapsulate four probiotics (Lactobacillus acidophilus, L. casei, Bifidobacterium bifidum and B. longum). The objectives were to optimize the encapsulation of the probiotics using a response surface methodology (RSM), sequential quadratic programming (SQP) and genetic algorithm (GA) to evaluate the survival of microencapsulated probiotics under simulated gastro-intestinal conditions and storage. The results showed that incorporation prebiotics with calcium alginate as wall materials could improve the survivability of probiotics during encapsulation, simulated gastro-intestinal conditions and storage. The current study also suggested that the two-stage effort of obtaining a surface model using RSM, and optimizing this model using SQP and GA techniques was shown to be an effective approach. The SQP and GA all produced the optimal conditions with the SQP being the most efficient.
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