INVESTIGATIONS ON THE LIVER FUNCTION OF BROILER CHICKENS WITH EXPERIMENTAL AFLATOXICOSIS
2014
Valchev I | Kanakov D. | Hristov Ts. | Lazarov L. | Binev R | Grozeva N. | Nikolov Y
The present experiment aimed to evaluate the toxic effects of AFB1 through follow-up of changes in blood activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyltransferase (γGT), lactate dehydrogenase (LDH), alkaline phosphatase (AP) and liver morphology. Also, the possibility for effective alleviation or prevention of toxic effects of AFB1 by feed supplementation with the mycosorbent Mycotоx NG was evaluated. The experiments were conducted with 50 7-day-old Cobb broiler chickens allotted to one control and 4 experimental groups. The chickens were orally treated with 1 g/kg Mycotox NG, 0.5 mg/kg AFB1, 0.8 mg/kg AFВ1 и 0.5 mg/kg AFB1 + 1 g/kg Mycotox NG over 42 days. Blood samples for analysis were collected on days 21 and 42. Blood chemistry revealed that the groups receiving only AFB1 showed increased activities of studied enzymes and total bilirubin concentrations. Total protein, albumin, cholesterol, triglycerides and blood glucose were lower than respective control values. Histopathological changes consisted in various degree of dystrophy depending on the amount of ingested toxin. The addition of mycosorbent to the feed of group V reduced partially the deleterious impact of AFB1 as could be seen from blood biochemical changes and the lower frequency and severity of liver lesions.
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