The Antiproliferative Effects of Compounds Isolated from Schisandra chinensis
2014
Suh, W.S., Yeungnam University, Gyeongsan, Republic of Korea | Park, S.Y., Yeungnam University, Gyeongsan, Republic of Korea | Min, B.S., Catholic University of Daegu, Daegu, Republic of Korea | Kim, S.H., Korea Forest Research Institute, Seoul, Republic of Korea | Song, J.H., Korea Forest Research Institute, Seoul, Republic of Korea | Shim, S.H., Yeungnam University, Gyeongsan, Republic of Korea
We isolated twelve lignans and three terpenoids were isolated from the n-hexane fraction of Schisandra chinensis extract. Using spectroscopic data and comparison with available literature, the following compounds were identified: (1) wuweizisu C, (2) gomisin N, (3) deoxyschisandrin, (4) gomisin A, (5) schisandrin, (6) chamigrenal, (7) schisanlactone D, (8) methylgomisin O, (9) angeloylgomisin O, (10) (?)-gomisin L©�, (11) schisandronic acid, (12) (?)-gomisin L©�, (13) (+)-gomisin K3, (14) gomisin J, and (15) tigloylgomisin H. Notably, this was the first finding that compound (8) was isolated from this plant. Each compound was evaluated for its in vitro cytotoxic activities toward HL-60 (human leukemia), HeLa (human cervical carcinoma), and MCF-7 (breast cancer) cell lines. Compounds (7), (8), and (9) exhibited strong cytotoxic effects on HL-60 (IC50 7.37, 6.60, and 8.00 ¥�M, respectively), whereas compound (6) exhibited weak cytotoxicity towards MCF-7 (IC50 30.50 ¥�M). In addition, compound (8) showed the strongest activity towards HeLa cells (IC50 1.46 ¥�M).
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