Corticosteroid-induced hepatopathy in dogs
2015
Kondratjeva, J., Latvia Univ. of Agriculture, Jelgava (Latvia) | Birgele, E., Latvia Univ. of Agriculture, Jelgava (Latvia)
Corticosteroid therapy is often used on dogs (Canis lupus familiaris) to treat different kinds of diseases. One of the most common complications of corticosteroid use is steroid hepatopathy, a specific pathology only in dogs. The objective of this study was to determine whether and how significant the liver functional changes after one administration of different kinds of corticosteroids in standard dosages are. The study took place in private veterinary clinics in Riga, Latvia, during 2013 - 2014, with the permission of dogs’ owners. Twenty animals, which received corticosteroids due to present diagnosis, were divided into four groups. To reach the aim such corticosteroids as dexamethasone sodium phosphate, prednisolone acetate, methylprednisolone acetate and hydrocortisone aceponate were used in standard dosage one time to these dogs, respectively. Then, such blood serum enzymes as alaninaminotransferase (ALAT) and alkaline phosphatase (AP) were determined 24, 48 and 96 hours after the use of corticosteroids. It was discovered that the only one administration of dexamethasone sodium phosphate and methylprednisolone acetate in standard dosage can significantly increase (p is less than 0.05) ALAT and AP mean values in dogs. The corticosteroid prednisolone acetate was used once in standard dosage and hydrocortisone aceponate spray was used once and did not statistically significantly (p is greater than 0.05) change the values of alaninaminotransferase (ALAT) and alkaline phosphatase (AP) in dogs’ blood serum during this study.
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