Arsenic induced toxicity in broiler chicks and its amelioration with ascorbic acid: Clinical, hematological and pathological study
2016
Sharaf, R. (University of Agriculture, Faisalabad (Pakistan). Faculty of Veterinary Science) | Khan, A. (University of Agriculture, Faisalabad (Pakistan). Faculty of Veterinary Science) | Khan, M.Z. (University of Agriculture, Faisalabad (Pakistan). Faculty of Veterinary Science) | Hussain, I. | Abbas, R.Z. | Gul, S.T. | Mahmood, F. | Saleemi, M.K.
This study was conducted to observe the arsenic (As) toxicity lesions in birds and to know either Vit C ameliorates these toxic effects or not. One-day-old broilers chicks (n=72) procured from a local hatchery were randomly divided into four equal groups. First group was kept as control and second group was given As (50 mg/kg BW) via crop tubing. Third group received in addition to As, Vit C (250 mg/kg BW) whereas fourth group received only Vit C. Killing by neck dislocation of randomly selected six birds from each group was carried out on experimental days 0, 16 and 32 for collection of blood and tissues specimens. Arsenic treated birds showed clinical signs of toxicity throughout the experiment than all other groups. These clinical signs included decreased body weight and feed intake, dullness, open mouth breathing, increased thirst, ruffled feathers, pale comb, skin irritation and watery diarrhea which were not significant in any other group. As treated group showed a significant (P less than 0.05) decrease in hematological parameters. Severe gross and histopathological changes were observed in intestines, spleen and lungs of birds fed with As than all other groups. Decreased height of villi of middle portion of small intestines was also observed in As treated birds. Villi height in Vit C treated group increased as compared to control group. It was concluded that As induces severe toxic effects in broiler birds; however, these toxic effects can be partially ameliorated by Vit C.
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