Can we really treat Thalassemia major?
2016
Seyal, R.A. (Seyal Medical Centre, Multan (Pakistan). Dept. of Medicine) | Tareen, S.M. (Nishtar Medical Coll., Multan (Pakistan). Dept. of Medicine) | Awan, H.M. (Air Univ., Multan (Pakistan))
Plant species have proven to be an important source of treatment in different diseases, in particular certain malignant tumors. The cytotoxic efficacy of Fagonia cretica has long been a subject of interest. This particular interest in a patient of breast cancer helped us to ascertain the efficacy of this herbal plant in Thalassemia. In initial testing, we obtained encouraging results by using dried aerial parts of the whole plant. It obligated upon us a detailed study of the plant in Thalassemia. A powder of the dried aerial parts of the whole flowering plant was given in doses of 120mg/kg body weight. The hematological and clinical results in nine Thalassemia Major group, showed a decrease of the Hb F from 97.45 to 10.82% and increase of Hb A from 0.33 to 85.5% (P less than 0.05) after about nine months of treatment, when blood samples for electrophoresis were collected at least six weeks after transfusion. The size of the liver and spleen which were 4-9 cm palpable below costal margins before treatment were not palpable after nine-month treatment. Similarly, in all the six patients, suffering with Thalassemia intermedia total hemoglobin improved from 2.13-5.6 g (P less than 0.05). Mean values of hemoglobin before and after the treatment were 8.08 and 11.95 g, respectively. In the four patients suffering with Thalassemia minor mean values of Hb A2 were 5.25 and 3.30, respectively before and after; and the reduction in Hb A2 was significant with 0.13 to 3.77% (P less than 0.05).
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