Antimicrobial Activity of Flos Syzygii Aromatici Extracts against Mice Infected with Escherichia coli O157:H7
2017
Lee, S.M., Gyeongsang National University, Chinju, Republic of Korea | Son, S.E., Gyeongsang National University, Chinju, Republic of Korea | Lee, H.J., Gyeongsang National University, Chinju, Republic of Korea
The present study evaluated the antibacterial effect of Flos syzygii Aromatici methanolic extracts (FSAE). In addition, the effectiveness of FSAE against Escherichia coli O157:H7 infection was studied using ICR female mice. At 24 h after incubation of E. coli O157:H7, FSAE at the concentration of 0.269 (p less than 0.05), 0.538 (p less than 0.001) and 1.075 mg/mL (p less than 0.001) significantly inhibited the growth of E. coli O157:H7 compared to the control group. After single challenge with E. coli O157:H7, forty female ICR mice were divided into four experimental groups which were orally administered with saline (control), 0.538 (group 1), 1.075 (group 2) and 2.15 mg/mL (group 3) of FSAE, respectively. On the 3rd day, the number of fecal E. coli O157:H7 in group 2 (p less than 0.05) and group 3 (p less than 0.01) was significantly decreased compared to that in the control group. On the 7th day post-treatment, the number of fecal E. coli O157:H7 in all FSAE-treated groups was significantly decreased compared to that in the control group (group 1, p less than 0.05; group 2 and 3, p less than 0.001). According to the results of the present study, administration of FSAE to mice can reduce the severity of E. coli O157:H7 infection. Therefore, the current study suggests that FSAE could be a good candidate for the treatment of enteric infections in domestic animals.
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