Antihepatotoxic effect of ethanol extracts from steam-dried ginseng berry on D-galactosamine/lipopolysaccharide-sensitized mice
2017
Jang, S.K., Gangneung-Wonju National University, Gangneung, Republic of Korea | Park, J.S., Gangneung-Wonju National University, Gangneung, Republic of Korea | Ahn, J.W., Gangneung-Wonju National University, Gangneung, Republic of Korea | Jo, B., Gangneung-Wonju National University, Gangneung, Republic of Korea | Kim, H.S., Gangneung-Wonju National University, Gangneung, Republic of Korea | Kim, J., Gangneung-Wonju National University, Gangneung, Republic of Korea | Kim, S.Y., Gangneung-Wonju National University, Gangneung, Republic of Korea | Park, J.Y., Daejeon University, Daejeon, Republic of Korea | Lee, D.I., Chung-Ang University, Seoul, Republic of Korea | Park, H.Y., Chung-Ang University, Seoul, Republic of Korea | Joo, S.S., Gangneung-Wonju National University, Gangneung, Republic of Korea
The present study aimed to examine the hepatoprotective effects of ethanol extracts from steam-dried ginseng berry (SGBE) in both D-Galactosamine/Lipopolysaccharide (D-GalN/LPS)-sensitized mice and in vitro models. Our results clearly demonstrated that SGBE significantly reduced the level of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and lactate dehydrogenase in blood, and TNFα was normalized in 8 h after the treatment with DGalN/LPS. Coincidently, major organs remained unimpaired when compared to D-GalN/LPS control group. Moreover, p38, which stimulates expression of NAFLD-associated cytokines, was markedly inhibited when treated with SGBE. In vitro analysis revealed that the main components of SGBE, linoleic acid and ginsenoside Re/Rd, may play a role in protecting liver from D-GalN/LPS-induced toxicity. Finally, we concluded that SGBE may be a promising therapeutic agent for preventing damage to the liver.
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