Isolation of Flavonoid Glycosides with Cholinesterase Inhibition Activity and Quantification from Stachys japonica
2018
Agung Nugroho, Lambung Mangkurat University, Banjarbaru, Indonesia | Choi, J.S., Pukyong National University, Busan, Republic of Korea | Seong, S.H., Sangji University, Wonju, Republic of Korea | Song, B.M., Sangji University, Wonju, Republic of Korea | Park, K.S., Sangji University, Wonju, Republic of Korea | Park, H.J., Sangji University, Wonju, Republic of Korea
The three flavone glycosides, 4'-O-methylisoscutellarein 7-O-(6'''-O-acetyl)-β-D-allopyranosyl(1→2)-β-D-glucopyranoside (1), isoscutellarein 7-O-(6'''-O-acetyl)-β-D-allopyranosyl(1→2)-β-D-glucopyranoside (3), and isoscutellarein 7-O-β-D-allopyranosyl(1→2)-β-D-glucopyranoside (4) in addition to a flavonol glycoside, kaempferol 3-O-β-D-glucopyranoside (astragalin, 2), were isolated from Stachys japonica (Lamiaceae). In cholinesterase inhibition assay, compound 1 significantly inhibited aceylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities (IC50s, 39.94 μg/ml for AChE and 86.98 μg/ml for BChE). The content of isolated compounds were evaluated in this plant extract by HPLC analysis. Our experimental results suggest that the flavonoid glycosides of S. japonica could prevent the memory impairment of Alzheimer's disease.
Mostrar más [+] Menos [-]Palabras clave de AGROVOC
Información bibliográfica
Este registro bibliográfico ha sido proporcionado por Korea Agricultural Science Digital Library