Importanţa testului de transformare limfoblastică – indicator al imunităţii celulare
2015
Golban, R. (State Agrarian University of Moldova, Chisinau (Republic of Moldova)
This paper includes scientific research results related to the lymphoblastic transformation test (LTT) “in vitro” under the action of anticarburising antigens and purified protein derivative, as a result of stimulation of lymphocytes which are central cells of the immune system. It was studied the mechanism of the stimulated lymphocytes blastization, which proliferates due to their mitosis and it was practically determined a cellular population, which corresponds numerically and functionally to an immune high quality answer. At the same time, it was stated that due to blast transformations, lymphocytes leave the stage of immunological inactivity and pass to the kinetic stage, being capable to produce specific effects, both on other cells they cooperate with and on the antigenic substrate, which causes immunological reactions. We have also observed activated macrophage changes after the re-vaccination in young animals with 15.5 % of blasts, compared to the reference sample where stimulation indices were 3.5 %. Modifications of the nonspecific blast are necessary to evaluate the functional capacity of lymphocytes.
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