IGF2/IR/IGF1R pathway in tumor cells and myofibroblasts mediates resistance to EGFR inhibition in cholangiocarcinoma
2018
Vaquero, Javier | Lobe, Cindy | Tahraoui, Sylvana | Clapéron, Audrey | Mergey, Martine | Merabtene, Fatiha | Wendum, Dominique | Coulouarn, Cédric | Housset, Chantal | Desbois-Mouthon, Christèle | Praz, Françoise | Fouassier, Laura
Cholangiocarcinoma (CCA) is a desmoplastic tumor of the biliary tree in which epidermal growth factor receptor (EGFR) is overexpressed and contributes to cancer progression. Although, EGFR has been envisaged as a target for therapy, treatment with tyrosine kinase inhibitors (TKI) such as erlotinib did not provide therapeutic benefit in patients with CCA, emphasizing the need to investigate resistance mechanisms against EGFR inhibition.
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