Cell surface polysaccharides of Bifidobacterium bifidum induce the generation of Foxp3+ regulatory T cells
2018
Verma, Ravi | Lee, Changhon | Jeun, Eun-Ji | Yi, Jaeu | Kim, Kwang Soon | Ghosh, Ambarnil | Byun, Seohyun | Lee, Choong-Gu | Kang, Hye-Ji | Kim, Gi-Cheon | Jun, Chang-Duk | Jan¨, Gwénaël, | Suh, Chang-Hee | Jung, Ju-Yang | Sprent, Jonathan | Rudra, Dipayan | De Castro, Cristina | Molinaro, Antonio | Surh, Charles D. | Im, Sin-Hyeog
Dysregulation of intestinal microflora is linked to inflammatory disorders associated with compromised immunosuppressive functions of Foxp3+ T regulatory (Treg) cells. Although mucosa-associated commensal microbiota has been implicated in Treg generation, molecular identities of the “effector” components controlling this process remain largely unknown. Here, we have defined Bifidobacterium bifidum as a potent inducer of Foxp3+ Treg cells with diverse T cell receptor specificity to dietary antigens, commensal bacteria, and B. bifidum itself. Cell surface β-glucan/galactan (CSGG) polysaccharides of B. bifidum were identified as key components responsible for Treg induction. CSGG efficiently recapitulated the activity of whole bacteria and acted via regulatory dendritic cells through a partially Toll-like receptor 2–mediated mechanism. Treg cells induced by B. bifidum or purified CSGG display stable and robust suppressive capacity toward experimental colitis. By identifying CSGG as a functional component of Treg-inducing bacteria, our studies highlight the immunomodulatory potential of CSGG and CSGG-producing microbes.
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Este registro bibliográfico ha sido proporcionado por National Institute for Agricultural Research