Uticaj anti-inflamatornog efekta niacina na enzime jetre i oksidativni stres krava u ranoj laktaciji | Effects of anti-inflammatory effect of niacin on liver enzymes and oxidative stress of cows in early lactation
2020
Petrović, Kosta | Stojanović, Dragica
The goal of this study is to determine the effect of niacin on the inflammatory response andfunctional status of the liver (considered through liver enzyme activity) in cows in earlylactation. The experiment was performed on 30 Holstein-Friesian cows: 15 receiving niacinand 15 cows in negative control. Niacin was administered for two weeks before and twoweeks after calving. Blood was taken by venipuncture of v.coccigea in cows before feeding inthe morning, at the time of calving, and then one and two weeks after calving. Niacinadministration leads to a decrease in the concentration of tumor necrosis factor alpha (TNFα), haptoglobin and nonesterified fatty acid (NEFA). The correlation between liver enzymes(AST, GGT) and MDA with NEFA was controlled via TNF-α. Niacin, in addition to itsantilipolitic effect, also exhibits an anti-inflammatory effect, which may be a significantmechanism in the protection of hepatocytes in early lactation in dairy cows. The influence ofniacin on TNF-α has been shown to be of great importance, as this cytokine controls thecorrelation between liver functional status index, lipolysis, and the inflammatory response.
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