Dynamics of catalysis and inhibition in oligopeptidases: natural peptide structures as promising antihypertensive agents.
2006
FERNANDEZ, J. H. | RIOLI, V. | NESHICH, G. | FERRO, E. S. | PORTARO, F. C. | CAMARGO, A. C. M.
ISMB, X-MEETING 2006. Poster E-8.
Mostrar más [+] Menos [-]Inglés. Short Abstract: Molecular modeling, combined with docking and molecular dynamics experiments was used to study the dynamics of catalysis/inhibition in ?druggable? human Oligopeptidases. The dynamics of ligand recognition and structural determinants for selective inhibition of these enzymes lead us to propose more selective oligopeptidase inhibitors with improved stability and pharmacological profile.
Mostrar más [+] Menos [-]Palabras clave de AGROVOC
Información bibliográfica
Este registro bibliográfico ha sido proporcionado por Empresa Brasileira de Pesquisa Agropecuária