Anti-inflammatory activity of flavonol glycosides from Erythrospermum monticolum depending on single or repeated local TPA administration
1995
Recio, M.C. del | Giner, R.M. | Manez, S. | Talens, A. | Cubells, L. | Gueho, J. | Julien, H.R. | Hostettmann, K. | Rios, J.L. (Valencia Univ. (Spain). Facultat de Farmacia. Dept. de Farmacologia)
Two anti-inflammatory principles were isolated from the methanol extract of the leaves of Erythrospermum monticolum (Flacourtiaceae). The isolation was based on a guided bioassay of the inhibitory activity on TPA-induced ear edema in mice. These compounds were identified as quercetin 3-O-xylosyl(1-2) rhamnoside and quercetin 3-O-rhamnoside. In addition, their effects on a chronic topic inflammation model were evaluated.
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