Insertion sequences of mycobacteria and their use in the study of epidemiology of mycobacterial infections
1999
Dvorska, L. | Bartl, J. | Pavlik, I. (Vyzkumny Ustav Veterinarniho Lekarstvi, Brno (Czech Republic)) | Havelkova, M. | Bartos, M.
The current studies on human and veterinary epidemiology have highly contributed to the detection of specific, small and mobile elements of the DNA - insertion sequences (IS). These sequences were: IS900 in Mycobacterium avium subspecies paratuberculosis, IS6110 in M. tuberculosis, and IS901 in M. avium complex. It has been ten years since the discovery of mycobacterial insertion sequences. Accordingly, the aim of this abstract was to present a summary of various research aspects and utilization of insertion sequences in mycobacteriology. The discovery, composition and function of IS are described in the introduction part. Priority has been given to the insertion sequences found in M. avium complex: IS902, IS1245, IS1311, IS1110, IS1141, IS1613; in M. tuberculosis: IS1081; and in some opportunic pathogenic mycobacteria (M. smegmatis, M. kansasii and M. fortuitum). The last section of the article deals with the use of insertion sequences in epidemiological and epizootological studies of mycobacterial infections caused by M. tuberculosis, M. bovis, M. a. paratuberculosis, and M. avium complex.
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