The immune response of ruminant livestock to bluetongue virus:From type I interferon to antibody
2014
Maclachlana, N. James | Henderson, Christine | Schwartz-Cornil, Isabelle | Zientara, Stephan
Infection of ruminants with most (but not all) serotypes of bluetongue virus (BTV) leads to a highly bloodcell-associated viremia that may be prolonged but not persistent. Furthermore, recovered animals areresistant to reinfection with the homologous virus serotype, which is the basis for vaccination strategiesto prevent BTV infection and the clinical disease (bluetongue) that it causes in domestic livestock. BTVinfection is initiated at the site of virus inoculation and the associated draining lymph node, from wherethe virus is then spread in lymph cells to the systemic circulation and secondary sites of replication.Replication of BTV in target cells, notably mononuclear phagocytic cells (dendritic cells and macrophages)and endothelium, leads to the generation of the innate and adaptive immune responses that mediate bothinitial virus clearance and subsequent resistance to infection with the homologous virus serotype. Thegoal of this review is to summarize current understanding of these innate and adaptive immune responsesof animals to BTV infection.
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