Recent developments of azidopurine and triazolylpurine chemistry at Rīga Technical University
Turks Turks, Māris Maris | Novosjolova,, Irina | Bizdēna Bizdena, Ērika Erika
Synthetic chemistry of nucleoside, nucleotide and nucleobase analogues is a constantly developing research field since the discovery of antiviral and anticancer agents in this compound group in the 1960s. Later the medicinal chemistry achievements were complemented by luminescent nucleobase analogues which have found their application in biological chemistry and very recently in materials science. The development of novel synthetic methods for substitution of purine and pyrimidine systems provides access to hitherto unknown derivatives that will allow medical chemists and materials scientists design new types of molecules and their applications. The team of researchers lead by Māris Turks, Ērika Bizdēna and Irina Novosjolova from the Faculty of Materials Science and Applied Chemistry, Rīga Technical University (RTU), was awarded the Diploma of the President of the Latvian Academy of Sciences for Achievements in Science 2020 for their work on “New synthetic methods in purine chemistry and their application in materials science”.
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